Kallikreins (KLKs) are a family of hormonally regulated serine proteinases comprising 15 related enzymes that are expressed in many tissues and cell types. The aim of this project is to gain insights into their localization in dermal fibroblasts, keratinocytes, thyroid epithelial and carcinoma cells. In addition, we want to study KLK trafficking upon thyroid stimulating hormone (TSH) treatment of thyroid cells.

Collaboration with and supported by: National Science Centre, Poland, ID 211744, Ref. 2013/08/W/NZ1/00696 Wplynal, “Extracellular proteolytic activity of human epithelium – role in the modulation of signal transduction”


  • Falkowski, K., E. Bielecka, I.B. Thøgersen, O. Bochenska, K. Płaza, M. Kalinska, L. Sasiadek, M. Magoch, A. Pecak, M. Wisniewska, N. Gruba, M. Wysocka, A. Wojtysiak, M. Brzezinska-Bodal, K. Sychowska, A. Pejkovska, M. Rehders, G. Butler, C.M. Overall, K. Brix, G. Dubin, A. Lesner, A. Kozik, J.J. Enghild, J. Potempa, and T. Kantyka (2020) Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs) — A CleavEx Based Analysis. Int. J. Mol. Sci. 21(12), 4383. https://doi.org/10.3390/ijms21124383.
  • Gruba, N. / E. Bielecka, M. Wysocka, A. Wojtysiak, M. Brzezińska-Bodal, K. Sychowska, M. Kalińska, M. Magoch, A. Pęcak, K. Falkowski, M. Wiśniewska, L. Sąsiadek, K. Płaza, E. Kroll, A. Pejkovska, M. Rehders, K. Brix, G. Dubin, T. Kantyka, and J. Potempa / A. Lesner (2019) Development of chemical tools to monitor human kallikrein 13 (KLK13) activity. Int. J. Mol. Sci. 20(7). pii: E1557. https://doi.org/10.3390/ijms20071557