Kallikreins (KLKs) are a family of hormonally regulated serine proteinases comprising 15 related enzymes that are expressed in many tissues and cell types. The aim of this project is to gain insights into their localization in dermal fibroblasts, keratinocytes, thyroid epithelial and carcinoma cells. In addition, we want to study KLK trafficking upon thyroid stimulating hormone (TSH) treatment of thyroid cells.
Collaboration with and supported by:
National Science Centre, Poland, ID 211744, Ref. 2013/08/W/NZ1/00696 Wplynal, “Extracellular proteolytic activity of human epithelium – role in the modulation of signal transduction”, by Prof. Dr. Jan S. Potempa / Dr. Tomasz Kantyka (Partner 1), Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland; Dr. Grzegorz Dubin (Partner 2), Malopolskie Centrum Biotechnologii, Krakow, Poland; Dr. hab. Adam Jerzy Lesner (Partner 3), Faculty of Chemistry, University of Gdansk, Poland; Prof. Dr. Klaudia Brix (Partner 4), Jacobs University Bremen, Germany; 2015 – 2017