Research Projects Brix – Proteases in the CNS

The significance of cysteine cathepsins for proper brain development is investigated in mouse models by combining behavioral studies with biochemical and cell biological approaches in order to explain the observed learning and memory phenotypes on the molecular level.


  • Dauth, S., H. Rakov, R.F. Sirbulescu, I. Ilies, J. Weber, B. Batbajar Dugershaw, D. Braun, M. Rehders, E.K. Wirth, D. Führer, U. Schweizer, and K. Brix (2020) Function of cathepsin K in the central nervous system of male mice is independent of its role in the thyroid gland. Cell. Mol. Neurobiol. 40, 695-710. SharedIt
  • Dauth, S. / M.M. Schmidt, M. Rehders, F. Dietz, S. Kelm, and R. Dringen / K. Brix (2012). Characterization and metabolism of astroglia-rich primary cultures from cathepsin K-deficient mice. Biol. Chem. 393, 959-970. doi: 10.1515/hsz-2012-0145;
  • Dauth, S., R.F. Sirbulescu, S. Jordans, M. Rehders, L. Avena, J. Oswald, A. Lerchl, P. Saftig, and K. Brix (2011). Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits. BMC Neuroscience 12, 74. doi:10.1186/1471-2202-12-74; Highly Accessed;
  • Dauth, S., M. Arampatzidou, M. Rehders, D.M.T. Yu, D. Führer, and K. Brix (2011). Thyroid cathepsin K – roles in physiology and thyroid disease. Clin. Rev. Bone Miner. Metab. 9, 94-106. doi:10.1007/s12018-011-9093-7;