Priority Programme “THYROID TRANS ACT – Translation of Thyroid Hormone Actions beyond Classical Concepts” (SPP 1629 – Dagmar Führer, Klaudia Brix, Heike Biebermann) by the Deutsche Forschungsgemeinschaft, 2012 – 2015 – 2018. Thyroid Trans Act asks “What defines healthy and diseased thyroid functions?” For further information: www.thyroidtransact.de
Molecular Cell Biology – Biomedicine of Proteolysis
The main interest of our research group is on the significance of proteolysis in epithelia like epidermis of the skin, intestinal mucosa, and the thyroid gland. We focus on cathepsins of the cysteine peptidase family and analyze their involvement in physiological versus pathological conditions using human and rodent cell lines, and advanced cell labeling techniques. Recently, we started to work on hormone-regulated proteases, the kallikreins. We generate fluorescent protein-tagged proteases as tools to visualize the transport pathways of proteolytic enzymes in eukaryotic cells by live-cell imaging, and study the function of cysteine cathepsins in systemic approaches comprising transgenic mouse models. Our research group has a cell biological orientation and integrates itself into the research network provided by the Molecular Life Scientists at Jacobs University Bremen. Our research activities cover proteases of the thyroid gland, the gastro-intestinal tract, and the central nervous system. More over proteases important for cell migration during wound healing of the skin and in thyroid cancer are studied in detail. Recently, we became involved in studying G-protein coupled receptors like the trace amine-associated receptors and their significance for thyroid regulation.
Our main research interests are in the field of
- bioactivity and cytotoxicity of substances from Rhododendron leaves and several other plants
- biomedical significance of proteolysis in epithelial organs
- protein trafficking and protein transport logistics in mammalian cells
- importance of cysteine cathepsins, legumain, and kallikreins