Klaudia Brix                                                               

Research Interests: Molecular Cell Biology – Biomedicine of Proteolysis

  • bioactivity and cytotoxicity of substances from Rhododendron leaves and several other plants
  • biomedical significance of proteolysis in epithelial organs
  • GPCR trafficking and significance in the central nervous system and for thyroid regulation
  • importance of cysteine peptidases and kallikreins
  • for maintenance of the physiological function of the thyroid gland
  • for migration of keratinocytes during intra-epidermal differentiation and during wound healing
  • for proliferation and differentiation of intestinal cells in physiology, pathology, and regeneration
  • for learning and memory functions of the brain


EJCB – European Journal of Cell Biology – Editorial Board

Protoplasma – An International Journal of Animal and Plant Cell Biology – Review Editor (Animal Cell Biology)



2017 – Chair of Gordon Research Conference “Protein Processing, Trafficking and Secretion”, July 15-20, 2018, Colby-Sawyer College, New London, NH, U.S.A.
2012 – Co-Coordinator of the SPP 1629 “THYROID TRANS ACT – Translation of Thyroid Hormone Actions beyond Classical Concepts”
Chair of Gordon Research Conference “Proteolytic Enzymes & Their Inhibitors”, June 17-22, 2012, Il Ciocco, Lucca (Barga), Italy
Vice-President of International Proteolysis Society
Council Member of International Proteolysis Society, Representative of Europe and Africa
Mentor Recognition Award, University of California San Diego, U.S.A.

Funded Projects

  • DFG grant BR 1308/13-2 “Coordination” of SPP 1629 “THYROID TRANS ACT – Translation of Thyroid Hormone Actions beyond Classical Concepts” – Priority Program; Führer, Brix, Biebermann. 2015 – 2018
  • DFG grant BR 1308/11-2 „Auto-regulation of the thyroid gland by classical and non-classical pathways“ in the framework of SPP 1629 THYROID TRANS ACT; PI: Klaudia Brix. 2015 – 2018
  • DAAD–Deutscher Akademischer Austauschdienst, Research Grants – Doctoral Programmes in Germany, PRNo 91534725, to MSc Alaa Al-Hashimi for doctoral studies on the project “Nuclear Cysteine Cathepsins in Thyroid Carcinoma”, 2015 – 2017
  • National Science Centre, Poland, ID 211744, Ref. 2013/08/W/NZ1/00696 Wplynal, “Extracellular proteolytic activity of human epithelium – role in the modulation of signal transduction”, by Prof. Dr. Jan S. Potempa / Dr. Tomasz Kantyka (Partner 1), Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland; Dr. Grzegorz Dubin (Partner 2), Malopolskie Centrum Biotechnologii, Krakow, Poland; Dr. hab. Adam Jerzy Lesner (Partner 3), Faculty of Chemistry, University of Gdansk, Poland; Prof. Dr. Klaudia Brix (Partner 4), School of Engineering and Science, Jacobs University Bremen, Germany; awarded July 2013; 2015 – 2017


  • American Society for Cell Biology (ASCB)
  • British Society for Matrix Biology (BSMB), 2007 – 2013
  • Deutsche Gesellschaft für Endokrinologie (DGE), since 2013; therein: Sektion Schilddrüse
  • Deutsche Gesellschaft für Zellbiologie (DGZ)
  • Deutscher Hochschulverband (DHV)
  • European Society of Endocrinology (ECE), since 2007
  • European Thyroid Association (ETA), since 2009
  • International Proteolysis Society (IPS), since 1999
  • New York Academy of Sciences (NYAS), by invitation, since 2008

University Education

Habilitation and Venia legendi in Cell Biology, Univ. Bonn, Germany
Dissertation (Dr. rer. nat.) in Biology, Univ. Bonn, Germany
Diploma in Biology, Univ. Bonn, Germany

Fellowships and Awards

“Lise-Meitner-Habilitationsstipendiatin”, Ministry of Science and Research
of Nordrhein-Westfalen, Germany
Scholarship Holder “Graduiertenförderung”, Ministry of Science and
Research of Nordrhein-Westfalen, Germany

Research and Teaching Positions

Vice-Speaker of the Molecular Life Science Research Center, Jacobs University Bremen
since 01/2006
Full Professor of Cell Biology, Jacobs University Bremen (formerly: International
University Bremen), Bremen, Germany
Associate Professor of Cell Biology, International University Bremen, Bremen,
Assistant Professor (“Oberassistentin”) of Cell Biology; Member of the Research
Focus “Molecular Biology and Cell Biology”; Member and Research Group
Leader in the “Bonner Forum Biomedizin”, therein: Manager of the Program to
support young scientists in biomedical research, Scientific Supervisor
of the Reference Center for confocal laser scanning microscopy; Group Leader
of Project B9, SFB 284, DFG (Univ. Bonn)
Acting Professor of Cell Biology and Vice-Chairperson (Univ. Bonn)
“Wissenschaftliche Assistentin” of Cell Biology and Group Leader of Project B1,
SFB 284, DFG (Univ. Bonn)
Research Scientist (Univ. Düsseldorf)
Research Scientist in the Focus Project “Cytoskeleton”, DFG (Univ. Bonn)
Teaching Experience
Fall 2002
Lectures, Practical Courses, and BSc Thesis Supervisor in the Undergraduate Majors “Biochemistry and Cell Biology” and “Medicinal Chemistry and Chemical Biology”; BCCB Program Representative from Fall 2003 and Study Program Coordinator from Fall 2006 until Spring 2014; major contributions to the Curriculum Reforms in SES 2008 and 2012, and 3C-model adoption in AY 2015/16; University Studies Courses; Representative of the Specialization Area “Cellular and Molecular Biology” in the Graduate Program “MoLife”; Lectures, Journal Clubs, Laboratory Rotations, and MSc Theses Supervisor of Graduate Students of the Life Sciences Program “MoLife”
Fall 2002
Supervision of PhD-Students; Co-Supervision of PhD-Students; Host of visiting Students from Denmark, Germany, Greece, Poland, Slovenia, and Switzerland; external PhD-examiner for Universities in Africa, Australia and Europe
Independent Lecturer, Venia legendi in “Cell Biology”, Lectures, Practical Courses, Laboratory Courses, and Seminars for Students of Biology (Univ. Bonn)
Independent and Dependent Supervisor of 26 Diploma and 9 PhD Students (Univ. Bonn)
Lecturer in substitution of the responsible Professor (Univ. Bonn)
Teaching Associate in various Practical Courses (Univ. Bonn)


Academic Committees and Responsibilities
since 2005
Committee Member of International Center for Transdisciplinary Studies ICTS at Jacobs University Bremen
since 2004
Member of the Graduate Admissions Committee “MoLife”
since 2004
since 2003
Scientific Head and Coordinator of the Reference Center for Confocal Laser Scanning Microscopy at Jacobs University Bremen
since 2002
Biological Safety Officer, Radiation Safety Officer, Jacobs University Bremen (formerly IUB)
Organiser of the Molecular Life Sciences Seminar, School of Engineering and Science, IUB
Member of the Steering Committee, Faculty Club e.V., IUB, now University Club e.V. at Jacobs University Bremen
Member of the Academic Integrity Committee, International University Bremen
Member of the Committee for Biological Safety Regulations, Univ. Bonn
Member of the Advisory Board of the Representative for Equal Opportunity, Univ. Bonn
Committee Member of the Division of Biology, Member of the Faculty of Mathematics and Life Sciences, Vice Chairperson of the Institute of Cell Biology, Univ. Bonn
Representative of the Scientific Fellows of the Institute of Cell Biology, Univ. Bonn