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Klaudia Brix & Team

Brix Group

SPP1629_logo_2012-200x150-100x75SPP 1629 – Coordination: Klaudia Brix (basic), Heike Biebermann (translational), Dagmar Führer (clinical)
Priority Programme “THYROID TRANS ACT – Translation of Thyroid Hormone Actions beyond Classical Concepts” – Deutsche Forschungsgemeinschaft, 2012 – 2015, 2015 – 2018; www.thyroidtransact.de

Molecular Cell Biology – Biomedicine of Proteolysis

The main interest of our research is on the significance of proteolysis in epithelia like epidermis of the skin, intestinal mucosa, and the thyroid gland. We focus on cysteine cathepsins, legumain, and kallikreins, and analyze their involvement in physiological versus pathological conditions using human and rodent cell lines and advanced cell labeling techniques. We generate fluorescent protein-tagged proteases as tools to visualize the transport pathways of the enzymes in eukaryotic cells for live-cell imaging, and study the function of cysteine cathepsins in systemic approaches comprising transgenic mouse models. Our research group has a cell biological orientation and integrates itself into the research network provided by the Molecular Life Scientists at Jacobs University Bremen.

Our research activities cover:

  • plant-derived bioactive substances
  • proteases of the thyroid gland
  • proteases of the gastro-intestinal tract
  • proteases of the central nervous system with importance for memory and learning
  • proteases important for cell migration during wound healing of the skin
  • proteases important for thyroid cancer
  • proteases important for colon cancer